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Alfa Aesar™ KN-62

Potently and specifically inhibits calcium/calmodulin kinase II

Chemical Identifiers

Chemical Name or Material KN-62
CAS 127191-97-3
Molecular Formula C38H35N5O6S2
Linear Formula NH2(CH2)10NH2
Formula Weight 721.84
MDL Number MFCD00083180
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Description & Specifications


Formula Weight 721.84
Chemical Name or Material KN-62
CAS 127191-97-3
Molecular Formula C38H35N5O6S2
Recommended Storage −30° to −10°C
Quantity 1mg
MDL Number MFCD00083180
Physical Form Powder
Melting Point 65° to 67°C
Color Yellow
Linear Formula NH2(CH2)10NH2

It is used as a potent and selective inhibitor of CaMKII. KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 μM) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 μM of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).

Soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (0.93 mg/ml), methanol (10 mg/ml), DMSO (12 mg/ml), chloroform (20 mg/ml), ethanol (~1 mg/ml), 1:2 DMF:PBS (pH 7.2) (~0.3 mg/ml), and DMF & DMSO (~30 mg/ml).

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents.

Safety and Handling

−30° to −10°C