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KLRG1 Golden Syrian Hamster anti-Mouse, PE-Cy7, Clone: 2F1, eBioscience™

Golden Syrian Hamster Monoclonal Antibody

$162.40 - $413.25

Specifications

Antigen KLRG1
Clone 2F1
Host Species Golden Syrian Hamster
Gene Alias MAFA
Species Reactivity Mouse
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5015590 Life Technologies
LS25589380
25μg Each for $162.40
5015591 Life Technologies
LS25589382
100μg Each for $413.25
Specifications

Description

This 2F1 monoclonal antibody reacts with the mouse Killer cell Lectin-like Receptor G1 (KLRG1), also known as Mast cell Function-associated Antigen (MAFA). KLRG1 is a homodimer of glycosylated 30-38kDa subunits and contains a cytoplasmic motif similar to the immunoreceptor tyrosine-based inhibitory motif (ITIM). Rat MAFA was identified as an antigen specific to rat mast cells; however, the expression of mouse KLRG1/MAFA using 2F1 has not been detected on the surface of mouse mast cell lines, bone marrow-derived mast cells, or peritoneal mast cells. This antigen is expressed on approximately one-third of mouse NK cells and a subset of T cells. MHC class I molecules regulate KLRG1 via interactions with class I-specific inhibitory Ly49 molecules and SHP-1 signaling. Although KLRG1 and Ly49 are both lectin-like inhibitory receptors that are regulated by class I MHC expression, the effects of this on cell surface expression of these molecules are opposing, and the underlying regulatory mechanisms distinct.
Description & Specifications

Specifications

KLRG1
Golden Syrian Hamster
Mouse
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
2F1
MAFA
Flow Cytometry
PE-Cy7
Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Monoclonal
0.2mg/mL