Please login to your online account to display your discounted pricing

KLRG1 Golden Syrian Hamster anti-Mouse, eFluor 450, Clone: 2F1, eBioscience™

Golden Syrian Hamster Monoclonal Antibody

$158.05 - $390.05

Specifications

Antigen KLRG1
Clone 2F1
Host Species Golden Syrian Hamster
Gene Alias MAFA
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

50246017

 
affymetrix
48589380
25μg Each for $158.05

50246018

 
affymetrix
48589382
100μg Each for $390.05
Description & Specifications

Specifications

Antigen KLRG1
Clone 2F1
Host Species Golden Syrian Hamster
Gene Alias MAFA
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate eFluor 450
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

This 2F1 monoclonal antibody reacts with the mouse Killer cell Lectin-like Receptor G1 (KLRG1), also known as Mast cell Function-associated Antigen (MAFA). KLRG1 is a homodimer of glycosylated 30-38kDa subunits and contains a cytoplasmic motif similar to the immunoreceptor tyrosine-based inhibitory motif (ITIM). Rat MAFA was identified as an antigen specific to rat mast cells; however, the expression of mouse KLRG1/MAFA using 2F1 has not been detected on the surface of mouse mast cell lines, bone marrow-derived mast cells, or peritoneal mast cells. This antigen is expressed on approximately one-third of mouse NK cells and a subset of T cells. MHC class I molecules regulate KLRG1 via interactions with class I-specific inhibitory Ly49 molecules and SHP-1 signaling. Although KLRG1 and Ly49 are both lectin-like inhibitory receptors that are regulated by class I MHC expression, the effects of this on cell surface expression of these molecules are opposing, and the underlying regulatory mechanisms distinct.