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Tocris™ JIB 04

Pan Jumonji inhibitor; active in vivo

$199.90 - $838.64


Product Type JIB 04
Inhibitors JIB 04
Molecular Weight 308.76
Purity >99
View More Specs


For Research Use Only

Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
497210R Tocris™
10mg Each for $199.90
497250R Tocris™
50mg Each for $838.64


Pan Jumonji histone demethylase inhibitor (IC50 values are 230, 340, 435, 445, 855 and 1100nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). Exhibits negligible activity at PHD2 and TET1. Selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo. Prolongs survival in a mouse model of breast cancer.
  • Chemical Name: 5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine
  • Formula: C17H13ClN4
  • CAS Number: 199596-05-9
  • Solubility: Soluble to 100mM in DMSO and to 50mM in 1eq. HCl
  • Purity: >99
Description & Specifications


JIB 04
JIB 04