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Jagged 2 Armenian Hamster anti-Mouse, eFluor 660, Clone: HMJ2-1, eBioscience™

Armenian Hamster Monoclonal Antibody

$143.55 - $361.05

Specifications

Antigen Jagged 2
Clone HMJ2-1
Host Species Armenian Hamster
Gene Alias Jag2
Species Reactivity Mouse, Rat
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501124341

 
affymetrix
50339280
25μg Each for $143.55

501124342

 
affymetrix
50339282
100μg Each for $361.05
Description & Specifications

Specifications

Antigen Jagged 2
Clone HMJ2-1
Host Species Armenian Hamster
Gene Alias Jag2
Species Reactivity Mouse, Rat
Applications Flow Cytometry
Regulatory Status RUO
Conjugate eFluor 660
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

This HMJ2-1 monoclonal antibody reacts with mouse Jagged-2, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g., Notch 1-4), Jagged-2 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases an intracellular fragment whose biological function remains controversial. Jagged-2 is expressed by thymic lymphoid and stromal cells, as well as macrophages and dendritic cells in the spleen.

Note: Staining of endogenous splenic dendritic (CD8+CD11c+) cells could only be consistently confirmed in cells isolated from C57BL/6, but not Balb/c, mice. Other strains have not been tested. The antiobdy has been reported to crossreact to rat and have blocking function.