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Tocris™ J 147

Neuroprotective and neurotrophic compound; reduces Abeta40 and Abeta42 levels

$199.20 - $841.81

Specifications

Product Type J 147
Inhibitors J 147
Molecular Weight 350.33
Purity >99
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 Disclaimers

For Research Use Only

Products
Catalog Number Mfr. No. Quantity Price Quantity    

508110R

 
tocris™
5081/10
10mg Each for $199.20

508150R

 
tocris™
5081/50
50mg Each for $841.81
Description & Specifications

Specifications

Product Type J 147
Inhibitors J 147
Molecular Weight 350.33
Purity >99

Potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200nM). Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's Disease mice, respectively. Orally active.

  • Chemical Name: 2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
  • Formula: C18H17F3N2O2
  • CAS Number: 1146963-51-0
  • Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
  • Purity: >99