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ITK Mouse, Clone: 2F12, eBioscience™

Mouse Monoclonal Antibody

$158.05 - $404.55

Specifications

Antigen ITK
Clone 2F12
Host Species Mouse
Gene Alias IL-2 inducible T-cell kinase
Species Reactivity Human, Mouse, Rat
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122821

 
affymetrix
14975280
25μg Each for $158.05

501122822

 
affymetrix
14975282
100μg Each for $404.55
Description & Specifications

Specifications

Antigen ITK
Clone 2F12
Host Species Mouse
Gene Alias IL-2 inducible T-cell kinase
Species Reactivity Human, Mouse, Rat
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Microscopy
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody 2F12 recognizes human, mouse, and rat ITK. ITK (also known as Interleukin-2 inducible T-cell kinase, T-cell-specific kinase, Tyrosine-protein kinase Lyk, Emt, and Tsk) is a member of the Tec family of kinases that include Tec, Btk, Bmx, and Txk. Tec family kinases play an indispensable role in activation of phospholipase C and activation of calcium-dependent signaling cascades following antigen receptor triggering. ITK is highly expressed by T cells and is required for optimal TCR-induced PLCγ1 activation. Mice congenitally lacking ITK show profound defects in T cell development and signaling. Defects in ITK are the cause of lymphoproliferative syndrome EBV-associated autosomal type 1 (LPSA1). ITK also plays a role in the development of various T cell mediated inflammatory disorders such as atopic dermatitis, psoriasis, and allergic asthma.