Please login to your online account to display your discounted pricing

ISG15 Armenian Hamster anti-Mouse, Clone: 3C2, eBioscience™

Armenian Hamster Monoclonal Antibody

$201.55 - $404.55

Specifications

Antigen ISG15
Clone 3C2
Host Species Armenian Hamster
Gene Alias ISG-15
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013219

 
affymetrix
14-5857-80
25μg Each for $201.55

5013220

 
affymetrix
14-5857-82
100μg Each for $404.55
Description & Specifications

Specifications

Antigen ISG15
Clone 3C2
Host Species Armenian Hamster
Gene Alias ISG-15
Species Reactivity Mouse
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

This 3C2 monoclonal antibody reacts with mouse interferon stimulated gene-15 (ISG-15), a 15kDa ubiquitin-like protein (UBL) and cytokine. ISG-15 is translated as a precursor that is subsequently activated by an E1 enzyme, conjugated by an E2 enzyme via the C-terminal LRLRGG motif and ligated by an E3 ligase. The activity of ISG-15 is dependent on its modification of target proteins at specific lysine residues. Several viruses utilize ISG-15 and ubiquitin deconjugating proteases, while influenza B protein NS1 has been shown to specifically bind ISG-15 thereby blocking its conjugation.

In addition to its role as a protein modification, ISG-15 is secreted by monocytes and lymphocytes in response to IFNα, β, or γ, as well as influenza B virus. In this role as cytokine, it has been shown to induce secretion of IFNγ and support NK cell proliferation and cytolytic activity.