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IRF8 Mouse anti-Human, Mouse, PerCP-eFluor 710, Clone: V3GYWCH, eBioscience™

Mouse Monoclonal Antibody

$174.24 - $443.52

Specifications

Antigen IRF8
Clone V3GYWCH
Host Species Murine
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501123968 Life Technologies
LS46985280
25μg Each for $174.24
501123969 Life Technologies
LS46985282
100μg Each for $443.52
Specifications

Description

The V3GYWCH monoclonal antibody reacts with human and mouse interferon regulatory factor 8 (IRF8; ICSBP). IRF8 is a 50kDa transcription factor that plays a critical role in the development of dendritic cells (DC). Specifically, IRF8 is essential in the development and differentiation of plasmacytoid DC (pDC) and CD8a+ DC. IRF8-/- mice are deficient in both pDC and CD8a+ DC populations. CD8a- DC are present in normal numbers in IRF8-/- mice but fail to mature upon Toll-like receptor signaling and are functionally impaired in response to in vivo microbial stimulation. IRF8 deficiency does not affect the frequency or viability of DC precursors and as a result retroviral IRF8 transduction restores pDC development from DC progenitors in IRF8-/- mice.
Description & Specifications

Specifications

IRF8
Murine
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
V3GYWCH
Flow Cytometry (Intracellular Staining)
PerCP-eFluor 710
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
0.2mg/mL