Please login to your online account to display your discounted pricing

IRF8 Mouse anti-Human, Mouse, PerCP-eFluor 710, Clone: V3GYWCH, eBioscience™

Mouse Monoclonal Antibody

$187.05 - $477.05

Specifications

Antigen IRF8
Clone V3GYWCH
Host Species Mouse
Species Reactivity Human, Mouse
Applications Flow Cytometry (Intracellular Staining)
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123968

 
affymetrix
46985280
25μg Each for $187.05

501123969

 
affymetrix
46985282
100μg Each for $477.05
Description & Specifications

Specifications

Antigen IRF8
Clone V3GYWCH
Host Species Mouse
Species Reactivity Human, Mouse
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate PerCP-eFluor 710
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The V3GYWCH monoclonal antibody reacts with human and mouse interferon regulatory factor 8 (IRF8; ICSBP). IRF8 is a 50kDa transcription factor that plays a critical role in the development of dendritic cells (DC). Specifically, IRF8 is essential in the development and differentiation of plasmacytoid DC (pDC) and CD8a+ DC. IRF8-/- mice are deficient in both pDC and CD8a+ DC populations. CD8a- DC are present in normal numbers in IRF8-/- mice but fail to mature upon Toll-like receptor signaling and are functionally impaired in response to in vivo microbial stimulation. IRF8 deficiency does not affect the frequency or viability of DC precursors and as a result retroviral IRF8 transduction restores pDC development from DC progenitors in IRF8-/- mice.