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IRF7 Rat anti-Mouse, PE, Clone: MNGPKL, eBioscience™

Rat Monoclonal Antibody

$158.05 - $419.05

Specifications

Antigen IRF7
Clone MNGPKL
Host Species Rat
Gene Alias Interferon Regulatory Factor 7
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122334

 
affymetrix
12582980
25μg Each for $158.05

501122335

 
affymetrix
12582982
100μg Each for $419.05
Description & Specifications

Specifications

Antigen IRF7
Clone MNGPKL
Host Species Rat
Gene Alias Interferon Regulatory Factor 7
Species Reactivity Mouse
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The monoclonal antibody MNGPKL reacts with mouse interferon regulatory factor 7 (IRF7), a 54kDa transcription factor essential for induction of the antiviral innate immune response and IFN alpha production. B cells, plasmacytoid dendritic cells (pDC), and monocytes constitutively express IRF7 in the cytoplasm until activation by viral infection, double-stranded RNA or Toll-like receptor (TLR) signaling. CpG ODNs and single-stranded RNA, recognized by CD289 (TLR9) and TLR7, respectively, trigger IRF7 activation and upregulation. This activation promotes type I IFN response to disrupt pathogen and viral infection. These events cause IRF7 phosphorylation and translocation to the nucleus where it forms a homodimer to affect transcription.