missing translation for 'onlineSavingsMsg'
Learn More
Please login to your online account to display your discounted pricing

IRF4 Rat anti-Human, Mouse, PE-Cy7, Clone: 3E4, eBioscience™

Rat Monoclonal Antibody

$147.84 - $376.20

Specifications

Antigen IRF4
Clone 3.00E+04
Host Species Rat
Gene Alias Interferon regulatory factor 4
Species Reactivity Human, Mouse
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501123465 Life Technologies
LS25985880
25μg Each for $147.84
501123466 Life Technologies
LS25985882
100μg Each for $376.20
Specifications

Description

The monoclonal antibody 3E4 reacts with human and mouse interferon regulatory factor 4 (IRF4). IRF4 is a 52kDa transcription factor with roles in B cell, T cell and macrophage function. In B cells, IRF4 is highly expressed in mature plasma cells and plays a crucial role in their differentiation. IRF4 has been shown to interact with PU.1 and control the transcription of many B cell-specific genes including Prdm1, which encodes Blimp1. In T cells, IRF4 has been implicated in regulatory T (Treg), Th2, Th9 and Th17 cell development and function. This transcription factor is upregulated upon T cell activation and is expressed in mature T cells. Studies have shown that IRF4 directly induces Blimp1 expression in Tregs, leading to IL-10 expression. IRF4 has also been demonstrated to be involved in macrophage polarization and regulation. Lastly, in addition to its roles in normal immune function, IRF4 expression has been reported to be upregulated in many blood-related cancers.
Description & Specifications

Specifications

IRF4
Rat
Human, Mouse
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
3.00E+04
Interferon regulatory factor 4
Flow Cytometry (Intracellular Staining)
PE-Cy7
Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Monoclonal
0.2mg/mL