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Integrin Beta 7 Rat anti-Human, Mouse, FITC, Clone: FIB504, eBioscience™

Rat Monoclonal Antibody

$143.55 - $288.55

Specifications

Antigen Integrin Beta 7
Clone FIB504
Host Species Rat
Gene Alias Integrin b7, ITGB7
Species Reactivity Human, Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

509885

 
affymetrix
11586741
25 tests Each for $143.55

509886

 
affymetrix
11586742
100 tests Each for $288.55
Description & Specifications

Specifications

Antigen Integrin Beta 7
Clone FIB504
Host Species Rat
Gene Alias Integrin b7, ITGB7
Species Reactivity Human, Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate FITC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.125μg)/test

The FIB504 monoclonal antibody reacts with human and mouse integrin beta 7. Integrin beta 7 is a 130 kD glycoprotein which associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Main ligands for integrin alpha 4 beta 7 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the main ligand of integrin alpha E beta 7 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response. The FIB504 antibody has been reported to have blocking activity.