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Integrin alpha 4 beta 7 (LPAM-1) Rat anti-Mouse, Clone: DATK32 (DATK-32), eBioscience™

Rat Monoclonal Antibody

$85.55 - $332.05

Specifications

Antigen Integrin alpha 4 beta 7 (LPAM-1)
Clone DATK32 (DATK-32)
Host Species Rat
Species Reactivity Mouse
Applications Flow Cytometry
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013278

 
affymetrix
14588781
50μg Each for $85.55

5013280

 
affymetrix
14588785
500μg Each for $332.05

5013279

 
affymetrix
14588782
100μg Each for $129.05
Description & Specifications

Specifications

Antigen Integrin alpha 4 beta 7 (LPAM-1)
Clone DATK32 (DATK-32)
Host Species Rat
Species Reactivity Mouse
Applications Flow Cytometry
Applications Functional Assay
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The DATK32 monoclonal antibody binds to a combinatorial epitope of mouse LPAM-1 (α4β7), which is a heterodimer of the the 154kDa α4 subunit and the 130kDa β7 subunit. In mouse, the β7 subunit is found on the majority of mature lymphocytes and a small population of thymocytes and bone marrow cells. LPAM-1 is an integrin involved in the transendothelial migration of lymphocytes across high endothelial venules (HEV), and is know to bind several ligands including MAdCAM-1, VCAM-1 and fibronectin. Binding of the DATK32 monoclonal antibody has been shown to induce aggregation of the CD8+ T cell lymphoma TK1, and block LPAM-1-mediated cell adhesion.