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Integrin alpha 4 beta 7 (LPAM-1) Rat anti-Mouse, APC, Clone: DATK32 (DATK-32), eBioscience™

Rat Monoclonal Antibody

$143.55 - $361.05

Specifications

Antigen Integrin alpha 4 beta 7 (LPAM-1)
Clone DATK32 (DATK-32)
Host Species Rat
Species Reactivity Mouse
Applications Flow Cytometry
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123153

 
affymetrix
17588782
100μg Each for $361.05

5015234

 
affymetrix
17588780
25μg Each for $143.55
Description & Specifications

Specifications

Antigen Integrin alpha 4 beta 7 (LPAM-1)
Clone DATK32 (DATK-32)
Host Species Rat
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate APC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The DATK32 monoclonal antibody binds to a combinatorial epitope of mouse LPAM-1 (alpha 4/ beta 7), which is a heterodimer of the the 154kDa alpha 4 subunit and the 130kDa beta 7 subunit. In mouse, the beta 7 subunit is found on the majority of mature lymphocytes and a small population of thymocytes and bone marrow cells. LPAM-1 is an integrin involved in the transendothelial migration of lymphocytes across high endothelial venules (HEV), and is know to bind several ligands including MAdCAM-1, VCAM-1 and fibronectin. Binding of the DATK32 monoclonal antibody has been shown to induce aggregation of the CD8+ T cell lymphoma TK1, and block LPAM-1-mediated cell adhesion.