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Thermo Scientific™ Lab Vision™ Insulin Receptor (α -Subunit) Ab-1, Mouse Monoclonal Antibody


Ensure accurate, reproducible results in experiments with the Thermo Scientific™ Insulin Receptor (α-Subunit) Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS631P1ABX

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Catalog No. MS631P1ABX

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Description & Specifications

Specifications

Antigen Insulin Receptor (alpha-Subunit) Ab-1
Applications Immunoprecipitation
Classification Monoclonal
Clone 83-14
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Host Species Mouse
Immunogen IM-9 lymphocytes followed by purified insulin receptor
Isotype IgG2a kappa
Quantity 100µL
Regulatory Status RUO
Research Discipline Steroids Hormones and Growth Factors
Type Primary

Ensure accurate, reproducible results in experiments with the Thermo Scientific™ Insulin Receptor (α-Subunit) Ab-1, Mouse Monoclonal Antibody.

The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide-linked subunits in a Β-α-α-Β configuration. The Β-subunit (95kDa) possesses a single transmembrane domain, whereas the α-subunit (135kDa) is completely extracellular.

Host Species: Mouse

Clone: 83-14

Isotype: IgG2a/κ

Species Reactivity: Human. Weakly with Cow, Pig and Sheep. Does not react with rabbit, mouse and rat. Others not known.

Epitope: aa 469-592 (exon 7/8)

Immunogen: IM-9 lymphocytes followed by purified insulin receptor

Molecular Weight: 135kDa

Positive Control: IM-9 lymphocyte cells, Placenta

Cellular Localization: Membrane Ab-1 inhibits insulin binding and mimics insulin action. It is excellent for immunoprecipitation of alpha-subunit of IR.

Recommended for:

  • Immunoprecipitation
  • ELISA
  • Insulin-like Agonist
  • Inhibits (∽80%) Insulin Binding (10nM)
  • Tyrosine Kinase Assay (Ab-mediated capture on microplates)

Note:

USA: RUO; Int'l: RUO