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Tocris™ Indibulin

Microtubule destabilizer

$205.70 - $862.95

Specifications

Product Type Indibulin
Inhibitors Indibulin
Molecular Weight 389.83
Purity >98
View More Specs

Disclaimers:

For Research Use Only



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
372810R Tocris™
RDS372810
10mg Each for $205.70
372850R Tocris™
RDS372850
50mg Each for $862.95
Specifications

Description

Microtubule destabilizer that blocks tubulin polymerization (IC50 = 0.3μM). Blocks cell cycle progression at metaphase and displays antitumor activity against a variety of malignancies in vitro (IC50 values ranging from 0.036 - 0.285μM). Induces complete tumor remission in the Yoshida AH13 rat sarcoma model in vivo. Lacks neurotoxicity due to an ability to discriminate between posttranslationally modified tubulin in mature neuronal microtubules and less-modified tubulin present in immature neuronal or nonneuronal microtubules. Displays oral availability and efficacy towards MDR tumor cells.
  • Chemical Name: 2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide
  • Formula: C22H16ClN3O2
  • CAS Number: 204205-90-3
  • Solubility: Soluble to 25mM in DMSO
  • Purity: >98
Description & Specifications

Specifications

Indibulin
Indibulin
389.83
>98