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IL-8 Mouse anti-Human, eFluor 450, Clone: 8CH, eBioscience™

Mouse Monoclonal Antibody

$170.28 - $381.48

Specifications

Antigen IL-8
Clone 8CH
Host Species Murine
Gene Alias Interleukin-8, CXCL8, NAP-I
Applications Flow Cytometry (Intracellular Staining)
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
50246031 Life Technologies
LS48808841
25 Tests Each for $170.28
50246032 Life Technologies
LS48808842
100 Tests Each for $381.48
Specifications

Description

This 8CH monoclonal antibody reacts with human IL-8 (CXCL8), a pro-inflammatory CXC chemokine. It is synthesized as a 99 amino acid precursor protein that is further processed into one of four isoforms, with the most common being 72 or 77 amino acids in length. IL-8(77) is secreted primarily by endothelial cells and is thought to be a less potent neutrophil activator than the other forms. It is present at high levels during fetal development, where it mediates angiogenesis rather than inflammation. The predominant form present in adults is IL-8(72), which is expressed by monocytes, macrophages, epithelial cells, and fibroblasts in response to inflammatory stimuli, environmental stress, and steroid hormones. IL-8(72) is essential for the activation and recruitment of neutrophils to sites of inflammation, and has also been found to influence T cell migration. Signaling occurs through the G-protein coupled receptors CXCR1 or CXCR2. IL-8 transcripts are often upregulated in tumors, and it is associated with tumor angiogenesis and metastasis.
Description & Specifications

Specifications

IL-8
Murine
Flow Cytometry (Intracellular Staining)
eFluor 450
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
5μL (0.06μg)/test
8CH
Interleukin-8, CXCL8, NAP-I
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer