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IL-37 (IL-1F7) Mouse anti-Human, Clone: 37D12, eBioscience™

Mouse Monoclonal Antibody

$158.05 - $390.05

Specifications

Antigen IL-37 (IL-1F7)
Clone 37D12
Host Species Mouse
Gene Alias Interleukin-37, IL-1H4
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122726

 
affymetrix
14737980
25μg Each for $158.05

501122727

 
affymetrix
14737982
100μg Each for $390.05
Description & Specifications

Specifications

Antigen IL-37 (IL-1F7)
Clone 37D12
Host Species Mouse
Gene Alias Interleukin-37, IL-1H4
Species Reactivity Human
Applications Immunocytochemistry
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

This 37D12 monoclonal antibody reacts with human IL-37. IL-37 is a member of the interleukin 1 cytokine family and is also known as IL-1F7 and IL-1H4. IL-37 suppresses innate inflammatory and immune responses and exhibits anti-inflammatory characteristics resembling those of IL-1R8. IL-37 binds to the alpha chain of IL-18R with low affinity and does not recruit the essential signaling co-receptor IL-18 beta or mediate pro-inflammatory activity. IL-37 also binds to IL-18 binding protein (IL-18BP) and enhances the antagonistic effects of IL-18BP. IL-37 forms a trimeric complex with IL-18BP and IL-18R beta, which results in the blockade of IL-18 activity. Transcripts of IL-37 have been detected in human tissues, such as lung, testis, and colon tumors, as well as some human cell lines.