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RMST2-33 has been reported to bind and activate ST2 in in vitro assays.Description & Specifications
DescriptionThe RMST2-33 monoclonal antibody reacts with mouse ST2, also known as IL-33R or interleukin 1 receptor-like 1. ST2 is a member of the IL-1 receptor family. In the membrane-bound form, it consists of three extracellular immunoglobulin domains and an intracellular toll-interleukin-1 receptor domain. ST2 forms a dimer with IL-1R accessory protein in a ligand-dependent manner. IL-33/ST2 interaction induces the production of TH2 cytokines. ST2 also has a soluble isoform lacking transmembrane and intracellular toll-interleukin-1 receptor domains. It is believed that the soluble form functions as a decoy receptor that can block membrane bound IL-33/ST2 interaction. ST2 is expressed by TH2 lymphocytes, mast cells, eosinophils, basophils, innate lymphocytes, smooth muscle cells, and endothelial cells and is involved in host defense, allergy, and inflammation. IL-33/ST2 interaction has also been shown to be atheroprotective.
RMST2-33 has been reported to bind and activate ST2 in in vitro assays.
|Store at 2-8°C. Do not freeze. Light-sensitive material.|
|IL-1RL1, IL-1R4, T1|
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|