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IL-23 Mouse anti-Human, eFluor 660, Clone: 23dcdp, eBioscience™

Mouse Monoclonal Antibody

$196.68 - $460.68

Specifications

Antigen IL-23
Clone 23dcdp
Host Species Murine
Gene Alias Interleukin-23 p19
Species Reactivity Human
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5016475 Life Technologies
LS50782341
25 Tests Each for $196.68
5016476 Life Technologies
LS50782342
100 Tests Each for $460.68
Specifications

Description

This 23dcdp monoclonal antibody reacts with the p19 subunit of human IL-23. This heterodimeric cytokine is composed of two disulfide-linked subunits, p40 and p19. It is closely related to IL-12, with which it shares the p40 subunit. The IL-23 receptor is also heterodimeric and shares the IL-12Rβ1 chain with IL-12, while the IL-23R chain is unique to the IL-23 receptor complex. IL-23R signaling occurs through the Jak/STAT pathway and results in RORγt expression, which promotes maintenance and proliferation of T helper 17 (Th17) cells.

Dendritic cells and macrophages produce high levels of p40 and low levels of IL-23 in response to TLR2, TLR4, and TLR8 ligands and agonists of the β-glucan receptor, Dectin-1. This is due to the presence of monomer and dimer forms of p40, while only a small portion associates with p19 to form IL-23. Our studies suggest donor variability, expression kinetics and type of stimulant can result in variation in IL-23 expression levels. Recent publications suggest the p19 subunit may also exist in the absence of association with p40.
Description & Specifications

Specifications

IL-23
Murine
Human
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
23dcdp
Interleukin-23 p19
Flow Cytometry (Intracellular Staining)
eFluor 660
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
5μL (0.03μg)/test