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IL-22 Rat anti-Mouse, PerCP-eFluor 710, Clone: 1H8PWSR, eBioscience™

Rat Monoclonal Antibody

$274.05 - $535.05

Specifications

Antigen IL-22
Clone 1H8PWSR
Host Species Rat
Gene Alias Interleukin-22
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123902

 
affymetrix
46722180
25μg Each for $274.05

5016104

 
affymetrix
46722182
100μg Each for $535.05
Description & Specifications

Specifications

Antigen IL-22
Clone 1H8PWSR
Host Species Rat
Gene Alias Interleukin-22
Species Reactivity Mouse
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate PerCP-eFluor 710
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The 1H8PWSR monoclonal antibody reacts with mouse interleukin(IL)-22. IL-22 is a 20kDa member of the IL-10 cytokine family that is secreted primarily by Th17, NK cells, and some other T cells. In in vitro Th17 cultures, induction of IL-22 expression is greater in response to IL-23 than IL-6 or TGF-ß, suggesting that this cytokine may be secreted by more fully differentiated Th17 cells in vivo. A heterodimer consisting of IL-10R2 and IL-22R1 serves as the receptor for IL-22. Th17-secreted IL-22 binds to the IL-22 receptor complexon target cells to induce the expression of anti-microbial peptides ß-defensin-2 and ß-defensin-3. Recently, it was demonstrated that IL-22 is able to protect hosts against bacterial infections of the lungs and gut.