Please login to your online account to display your discounted pricing

IL-22 Rat anti-Human, Mouse, Clone: IL22JOP, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

$158.05 - $404.55

Specifications

Antigen IL-22
Clone IL22JOP
Host Species Rat
Gene Alias Interleukin-22, IL22
Species Reactivity Human, Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5014736

 
affymetrix
16-7222-82
100μg Each for $158.05

5014737

 
affymetrix
16722285
500μg Each for $404.55
Description & Specifications

Specifications

Antigen IL-22
Clone IL22JOP
Host Species Rat
Gene Alias Interleukin-22, IL22
Species Reactivity Human, Mouse
Applications Cytokine Neutralization
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide
Concentration 1mg/mL

The monoclonal antibody IL22JOP reacts with and inhibits the bioactivity of human and mouse IL-22. IL-22 is a 20kDa member of the IL-10 cytokine family that is secreted primarily by Th17 cells, NK cells, and other T cells. Compared to IL-6 or TGF beta, IL-23 can induce greater levels of IL-22 in in vitro-differentiated Th17 cells. This observation suggests that IL-22 may be secreted by more fully differentiated Th17 cells in vivo. Recently, it was demonstrated that IL-22 could protect hosts from bacterial infection of the lungs and gut. Moreover, it has been reported that anti-CD3/CD28-induced production of IL-22 by PBMCs was elevated significantly in asthma patients compared to control patients. Flow cytometric analysis also showed that the frequencies of IL-17+IL-22+ CD4 T cells were increased in PBMCs from patients with ankylosing spondylitis and rheumatoid arthritis.