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IL-22 Monoclonal Antibody (IL22JOP), APC, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Supplier: Invitrogen 17722280
Description
Description: The monoclonal antibody IL22JOP reacts with and inhibits the bioactivity of human and mouse IL-22. IL-22 is a 20 kDa member of the IL-10 cytokine family that is secreted primarily by Th17 cells, NK cells, and other T cells. Compared to IL-6 or TGF beta, IL-23 can induce greater levels of IL-22 in in vitro-differentiated Th17 cells. This observation suggests that IL-22 may be secreted by more fully differentiated Th17 cells in vivo. Recently, it was demonstrated that IL-22 could protect hosts from bacterial infection of the lungs and gut. Moreover, it has been reported that anti-CD3/CD28-induced production of IL-22 by PBMCs was elevated significantly in asthma patients compared to control patients. Flow cytometric analysis also showed that the frequencies of IL-17+IL-22+ CD4 T cells were increased in PBMCs from patients with ankylosing spondylitis and rheumatoid arthritis. IL22JOP is published to recognize rhesus IL-22. Applications Reported: This IL22JOP antibody has been reported for use in intracellular staining followed by flow cytometric analysis. Applications Tested: This IL22JOP antibody has been tested on Th17-polarized CD4+ normal human peripheral blood cells. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.
IL-22 Monoclonal antibody specifically detects IL-22 in Human, Mouse, Rhesus Monkey samples. It is validated for Flow Cytometry.Specifications
IL-22 | |
Monoclonal | |
0.2 mg/mL | |
PBS with 0.09% sodium azide; pH 7.2 | |
Q9GZX6, Q9JJY9 | |
IL22 | |
Affinity chromatography | |
RUO | |
50616, 50929, 718047 | |
4° C, store in dark, DO NOT FREEZE! | |
Liquid |
Flow Cytometry | |
IL22JOP | |
APC | |
IL22 | |
Cytokine Zcyto18; EGK_03903; il 22; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; IL-21; IL22; IL-22; Il22a; IL-22a; IL-D110; ILN; ILTIF; IL-TIF; ILTIF alpha; IL-TIF alpha; ILTIFa; Interleukin; interleukin 10-related T cell-derived inducible factor; interleukin 22; Interleukin22; interleukin-22; Interleukin-22a; RGD1561292; TIFa; TIFIL-23; UNQ3099/PRO10096; ZCYTO18 | |
Rat | |
25 μg | |
Primary | |
Human, Mouse, Rhesus Monkey | |
Antibody | |
IgG2a κ |
For Research Use Only.