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IL-21 Rat anti-Mouse, Clone: FFA21, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

$196.68 - $460.68

Specifications

Antigen IL-21
Clone FFA21
Host Species Rat
Gene Alias Interleukin-21
Species Reactivity Mouse
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122992 Life Technologies
LS16721182
100μg Each for $196.68
501129549 Life Technologies
LS16721185
500μg Each for $460.68
Specifications

Description

This FFA21 monoclonal antibody reacts with mouse interleukin-21 (IL-21). IL-21 is a 17kDa immunomodulatory cytokine produced mainly by NKT, T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1, IL-4 for Th2 and IL-17A for Th17, IL-21 is critical for TFH cell effector function. This cytokine plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naïve B cells.

In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. High levels of IL-21 are present in chemically-induced colitis models. IL-21-deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules.

Preliminary data suggest that clone FFA21 recognizes a different epitope than anti-mouse IL-21 clone mhalx21 (cat. 51-7213).
Description & Specifications

Specifications

IL-21
Rat
Mouse
RUO
Purified
Primary
aqueous buffer, no sodium azide
FFA21
Interleukin-21
Cytokine Neutralization
Unlabeled
Store at 2-8°C.
Monoclonal
1mg/mL