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IL-2 Rat anti-Mouse, APC, Clone: JES6-5H4, eBioscience™

Rat Monoclonal Antibody

Manufacturer:  Life Technologies LS17702182

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Catalog No. 501129277



Description

Description

Description: The JES6-5H4 antibody reacts with mouse interleukin-2 (IL-2), a 17 kDa T cell growth factor and a major immunoregulatory cytokine. Applications Reported: JES6-5H4 has been reported for use in intracellular flow cytometric analysis. Applications Tested: This JES6-5H4 antibody has been tested intracellular staininf of stimulated mouse splenocytes. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered.

Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.
Specifications

Specifications

IL-2
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P04351
Interleukin-2, T-cell growth factor, TCGF, Aldesleukin
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
JES6-5H4
APC
Il2
Liquid
Il2
IgG2b, kappa
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
16183
Documents

For Research Use Only.