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IL-17F Monoclonal Antibody (eBio18F10), eFluor™ 660, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Supplier:  Thermo Fisher Scientific 50747182

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Catalog No. 5016474



Description

Description

Description: The eBio18F10 antibody reacts with mouse IL-17F. IL-17F is a 37 kD homodimer of the IL-17 family and a signature Th17 marker. Of all the six IL-17 family members, IL-17F and IL-17A share the strongest homology (50% amino acid identity), and the two genes are located in the same chromosomal region. Recent studies have demonstrated coordinated regulation of IL-17A and IL-17F during Th17 differentiation. Expression of IL-17F and IL-17A has been detected in activated human peripheral blood lymphocytes, specifically by activated human CD4+ T cells. In addition to IL-17A, differentiated Th17 cells also produce IL-17F and IL-22 upon re-activation. Like IL-17A, IL-17F has been linked with inflammatory diseases. IL-17F and IL-17A expression has been observed in tissue samples from various autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, psoriasis, inflammatory bowel disease, and asthma. IL-17F treatment of airway epithelium, vein endothelial cells, and fibroblasts has been reported to induce expression of IL-6, IL-8, GRO-alpha, ENA-78, TGF-beta, MCP-1, G-CSF, GM-CSF, and ICAM-1. Like IL-17A, IL-17F is a disulfide-linked homodimeric glycoprotein. The IL-17F homodimer includes a classical cysteine knot motif, which is found also in the TGF-beta, BMP, and NGF superfamilies. The presence of the cysteine knot motif suggested the possibility of a heterodimeric structure, as was reported for TGF-beta and inhibin/activin.

IL-17F Monoclonal antibody specifically detects IL-17F in Mouse samples. It is validated for Flow Cytometry.
Specifications

Specifications

IL-17F
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q7TNI7
IL17F
Affinity chromatography
RUO
257630
4° C, store in dark, DO NOT FREEZE!
Liquid
Flow Cytometry
eBio18F10
eFluor 660
IL17F
C87042; CANDF6; cytokine ML-1; IL17F; IL-17F; IL-24; ILN; Interleukin; interleukin 17F; Interleukin17F; interleukin-17F; interleukin-24; ML1; ML-1; mutant IL-17F
Rat
100 μg
Primary
Mouse
Antibody
IgG2a κ
SDS
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For Research Use Only.