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IL-17F Rat anti-Human, Clone: SHLR17, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

$216.05 - $506.05

Specifications

Antigen IL-17F
Clone SHLR17
Host Species Rat
Gene Alias Interleukin-17F
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

50245632

 
affymetrix
16716982
100μg Each for $216.05

50245633

 
affymetrix
16716985
500μg Each for $506.05
Description & Specifications

Specifications

Antigen IL-17F
Clone SHLR17
Host Species Rat
Gene Alias Interleukin-17F
Species Reactivity Human
Applications Functional Assay
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide
Concentration 1mg/mL

This SHLR17 monoclonal antibody reacts with human interleukin (IL)-17F. IL-17F is a homodimeric, 34kDa member of the IL-17 family, which includes IL-17(A), B, C, D, E (IL-25). Within this family, IL-17A and IL-17F are produced preferentially by T helper 17 (Th17) cells, with other members produced more widely. IL-17F and IL-17A have many overlapping functions, but knockout studies have shown each to have independent functions as well. In vitro cultured Th17 cells have been shown to express IL-17F and IL-17A homodimers and IL-17A/F heterodimers depending on the culture conditions and their differentiation state. A heterodimer of IL-17RA and IL-17RC has been shown to bind IL-17F, resulting in target cell-secretion of pro-inflammatory cytokines and chemokines, as well as neutrophil recruitment.

This SHLR17 monoclonal antibody neutralizes the bioactivity of IL-17F homodimers without affecting IL-17A/F heterodimers.