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IL-17F Rat anti-Human, Clone: SHLR17, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

$196.68 - $460.68

Specifications

Antigen IL-17F
Clone SHLR17
Host Species Rat
Gene Alias Interleukin-17F
Applications Functional Assay
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
50245632 Life Technologies
LS16716982
100μg Each for $196.68
50245633 Life Technologies
LS16716985
500μg Each for $460.68
Specifications

Description

This SHLR17 monoclonal antibody reacts with human interleukin (IL)-17F. IL-17F is a homodimeric, 34kDa member of the IL-17 family, which includes IL-17(A), B, C, D, E (IL-25). Within this family, IL-17A and IL-17F are produced preferentially by T helper 17 (Th17) cells, with other members produced more widely. IL-17F and IL-17A have many overlapping functions, but knockout studies have shown each to have independent functions as well. In vitro cultured Th17 cells have been shown to express IL-17F and IL-17A homodimers and IL-17A/F heterodimers depending on the culture conditions and their differentiation state. A heterodimer of IL-17RA and IL-17RC has been shown to bind IL-17F, resulting in target cell-secretion of pro-inflammatory cytokines and chemokines, as well as neutrophil recruitment.

This SHLR17 monoclonal antibody neutralizes the bioactivity of IL-17F homodimers without affecting IL-17A/F heterodimers.
Description & Specifications

Specifications

IL-17F
Rat
Functional Assay
Unlabeled
Store at 2-8°C.
Monoclonal
1mg/mL
SHLR17
Interleukin-17F
RUO
Purified
Primary
aqueous buffer, no sodium azide