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IL-17A Monoclonal Antibody (eBio64DEC17), PE-Cyanine7, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
$252.00 - $566.00
Specifications
| Antigen | IL-17A |
|---|---|
| Clone | eBio64DEC17 |
| Concentration | 5 μL/Test |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
Description
Description: The eBio64DEC17 antibody reacts with human IL-17A. The eBio64DEC17 antibody is a neutralizing antibody. Interleukin-17A (IL-17A) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. The cDNA encoding human IL-17A was isolated from a library of CD4+ T cells; the encoded protein exhibits 72 percent amino acid identity with HVS13 , an open reading frame from a T lymphotropic Herpesvirus saimiri, and 63 percent with mouse CTLA-8 (cytotoxic T-lymphocyte associated antigen-8). Human IL-17A exists as glycosylated 20-30 kD homodimers. High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells. IL-17A enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. Human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse IL-17A receptor.
IL-17A Monoclonal antibody specifically detects IL-17A in Human samples. It is validated for Flow Cytometry.Specifications
| IL-17A | |
| 5 μL/Test | |
| Monoclonal | |
| Liquid | |
| RUO | |
| PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2 | |
| Ctla8; CTLA-8; cytokine; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; Il17; IL-17; IL17A; IL-17a; ILN; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17 precursor; interleukin 17A; interleukin-17; Interleukin17A; interleukin-17A; R-IL-17-A | |
| IL17A | |
| Primary | |
| 4° C, store in dark, DO NOT FREEZE! | |
| IL17A |
| eBio64DEC17 | |
| Flow Cytometry | |
| PE-Cyanine7 | |
| Mouse | |
| Human | |
| Q16552 | |
| 3605 | |
| IgG1 κ | |
| Affinity chromatography | |
| Antibody |
For Research Use Only.