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IL-15 Mouse anti-Human, Clone: ct2nu, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

$158.05 - $404.55

Specifications

Antigen IL-15
Clone ct2nu
Host Species Mouse
Species Reactivity Human
Applications Cytokine Neutralization
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5014238

 
life technologies
LS16015782
100μg Each for $158.05

5014239

 
life technologies
LS16015785
500μg Each for $404.55
Description & Specifications

Specifications

Antigen IL-15
Clone ct2nu
Host Species Mouse
Species Reactivity Human
Applications Cytokine Neutralization
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C. Avoid repeated freeze/thaw cycles. KEEP CONTENTS STERILE.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide
Concentration 1mg/mL

The ct2nu monoclonal antibody reacts with human IL-15 and neutralizes its bioactivity. IL-15, or IL-T, is a 14kDa proinflammatory cytokine and member of the IL-2 family. It plays a role in the development and maturation of macrophages and dendritic cells, and is essential to the proliferation and survival of NK cells and CD8+ T cells.

IL-15 is expressed by antigen-presenting cells, epithelial cells, and stromal cells. IL-15 activates the Jak/STAT pathway through its heterotrimeric receptor. Two subunits of this receptor, the β and γ chains, are shared with the rest of the family, while the α subunit is unique to IL-15. In mice, the α chain is required to chaperone IL-15 from the ER to secretion. This chaperoning is not necessary in humans, and free IL-15 is detectable in human biological samples. However, the receptor-cytokine complex has been indentified in humans and demonstrates agonistic activity several-fold higher than IL-15 alone.