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IL-1 beta Pro-form Rat anti-Mouse, FITC, Clone: NJTEN3, eBioscience™

Rat Monoclonal Antibody

$174.24 - $389.40

Specifications

Antigen IL-1 beta Pro-form
Clone NJTEN3
Host Species Rat
Gene Alias Interleukin-1 beta, IL-1F2
Species Reactivity Mouse
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5010010 Life Technologies
LS11711480
25μg Each for $174.24
5010011 Life Technologies
LS11711482
100μg Each for $389.40
Specifications

Description

This NJTEN3 monoclonal antibody reacts with the pro-form of mouse IL-1 beta, which is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized in response to inflammatory stimuli as a 31kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is instead secreted alongside caspase-1 via an alternate and incompletely understood mechanism. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. These cytokines play important roles in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses. Their activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions, giving IL-RA or IL-1 beta neutralizing antibodies potential therapeutical value.The NJTEN3 antibody recognizes only the pro-form of mouse IL-1 beta and does not see the active (cleaved) form.
Description & Specifications

Specifications

IL-1 beta Pro-form
Rat
Mouse
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
NJTEN3
Interleukin-1 beta, IL-1F2
Flow Cytometry (Intracellular Staining)
FITC
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
0.5mg/mL