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IGF-1R (α-subunit) Ab-4 Mouse Monoclonal Antibody, Epredia™
Epredia™ IGF-1R (α-Subunit) Ab-4, Mouse Monoclonal Antibody provides accurate, reproducible results.
Supplier: Thermo Fisher Scientific MS644PABX
Description
IGF-1R (Insulin-like Growth Factor-1 Receptor) consists of α- and Β-subunits, which are disulfide-linked in a Β-α-α-Β configuration in the mature receptor. The α-subunit is completely extracellular, while the Β-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity.Host Species: Mouse
Clone: 24-60
Isotype: IgG2a/κ
Species Reactivity: Human. Weakly reacts with Rabbit and Pig (Ab-2 is better). Does not react with rat.
Epitope: aa 184-283
Immunogen: IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA
Molecular Weight: 125kDa
Positive Control: Placenta or Breast CA
Cellular Localization: Membrane Ab-4 is excellent for immunoprecipitation of alpha-subunit of IGF-1R.
Recommended for:
- Western Blotting (Not suitable)
- Immunoprecipitation
- Acts as a Weak IGF-like Agonist in Bioassays (Thymidine incorporation into DNA)
- Substantially (>80%) Inhibits IGF-1 Binding
Note:
USA: RUO; Int'l: RUO
Specifications
| IGF-1R (alpha-Subunit) Ab-4 | |
| Monoclonal | |
| 1mg/mL | |
| Mouse | |
| 200 μL | |
| Neuroscience | |
| Human | |
| IgG2a κ |
| Immunoprecipitation | |
| 24-60 | |
| Unconjugated | |
| IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA | |
| RUO | |
| Primary | |
| Concentrated |