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Thermo Scientific™ Lab Vision™ IGF-1R (α -Subunit) Ab-4, Mouse Monoclonal Antibody


Ideal for immunoprecipitation, Thermo Scientific™ IGF-1R (α-Subunit) Ab-4, Mouse Monoclonal Antibody provides accurate, reproducible results.

Manufacturer: thermo scientific™ lab vision™  MS644P1ABX

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Catalog No. MS644P1ABX

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Description & Specifications

Specifications

Antigen IGF-1R (alpha-Subunit) Ab-4
Applications Immunoprecipitation
Classification Monoclonal
Clone 24-60
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Host Species Mouse
Immunogen IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA
Isotype IgG2a kappa
Quantity 100µL
Regulatory Status RUO
Research Discipline Neuroscience
Type Primary

Ideal for immunoprecipitation, Thermo Scientific™ IGF-1R (α-Subunit) Ab-4, Mouse Monoclonal Antibody provides accurate, reproducible results.

IGF-1R (Insulin-like Growth Factor-1 Receptor) consists of α- and Β-subunits, which are disulfide-linked in a Β-α-α-Β configuration in the mature receptor. The α-subunit is completely extracellular, while the Β-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity.

Host Species: Mouse

Clone: 24-60

Isotype: IgG2a/κ

Species Reactivity: Human. Weakly reacts with Rabbit and Pig (Ab-2 is better). Does not react with rat.

Epitope: aa 184-283

Immunogen: IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA

Molecular Weight: 125kDa

Positive Control: Placenta or Breast CA

Cellular Localization: Membrane Ab-4 is excellent for immunoprecipitation of alpha-subunit of IGF-1R.

Recommended for:

  • Western Blotting (Not suitable)
  • Immunoprecipitation
  • Acts as a Weak IGF-like Agonist in Bioassays (Thymidine incorporation into DNA)
  • Substantially (>80%) Inhibits IGF-1 Binding

Note:

USA: RUO; Int'l: RUO