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Thermo Scientific™ IGF-1R (α -Subunit) Ab-3, Mouse Monoclonal Antibody

Provide accurate, reproducible results with the Thermo Scientific™ IGF-1R (α-Subunit) Ab-3, Mouse Monoclonal Antibody.

$255.49 - $1,313.16

Specifications

Antigen IGF-1R (alpha-Subunit) Ab-3
Clone 24-57
Classification Monoclonal
Conjugate Unlabeled
Cross Reactivity Human
View More Specs
Products
Catalog Number Mfr. No. Concentration Quantity Price Quantity    

MS643P

 
thermo scientific™
MS-643-P
200�g/mL 1mL Each for $1,195.35

MS643P0

 
thermo scientific™
MS-643-P0
200�g/mL 100µL Each for $255.49

MS643P1

 
thermo scientific™
MS-643-P1
200�g/mL 500µL Each for $743.04

MS643P1ABX

 
thermo scientific™
MS643P1ABX
1mg/mL 100µL Each for $844.49

MS643PABX

 
thermo scientific™
MS-643-PABX
1mg/mL 200µL Each for $1,313.16
Description & Specifications

Specifications

Antigen IGF-1R (alpha-Subunit) Ab-3
Clone 24-57
Classification Monoclonal
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Rabbit
Cross Reactivity Human
Cross Reactivity Rabbit
Format Concentrated
Host Species Mouse
Regulatory Status RUO
Research Discipline Neuroscience
Type Primary
Immunogen IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA
Isotype IgG2a kappa

Provide accurate, reproducible results with the Thermo Scientific™ IGF-1R (α-Subunit) Ab-3, Mouse Monoclonal Antibody.

IGF-1R (Insulin-like Growth Factor-1 Receptor) consists of α- and Β-subunits, which are disulfide-linked in a Β-α-α-Β configuration in the mature receptor. The α-subunit is completely extracellular, while the Β-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity.

Host Species: Mouse

Clone: 24-57

Isotype: IgG1/κ

Species Reactivity: Human and Rabbit. Weakly reacts with Pig. Does not react with rat.

Epitope: aa 440-514 (exon 7/8)

Immunogen: IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA

Molecular Weight: 125kDa

Positive Control: Placenta or Breast CA

Cellular Localization: Membrane Ab-3 is the antibody-of-choice for blocking binding of IGF-1 to its receptor. It weakly mimics IGF-1 action. Ab-3 reacts only weakly with hybrids of Insulin Receptor and IGF-1R while Ab-5 reacts very well. So, Ab-3, in conjunction with Ab-5, has proved useful in the isolation of hybrid receptors.

Recommended for:

  • Western Blotting (Not suitable)
  • Immunoprecipitation (Not optimum)
  • Affinity Purification of Hybrid Receptors
  • Acts as a Weak IGF-like Agonist in Bioassays (Thymidine incorporation into DNA)
  • Inhibits (>90%) IGF-1 Binding

Note:

USA: RUO; Int'l: RUO