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Thermo Scientific™ IGF-1R (α -Subunit) Ab-3, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ IGF-1R (α-Subunit) Ab-3, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™  MS643P1ABX

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Catalog No. MS643P1ABX

  • / Each
 

Description & Specifications

Specifications

Antigen IGF-1R (alpha-Subunit) Ab-3
Classification Monoclonal
Clone 24-57
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Rabbit
Format Concentrated
Host Species Murine
Immunogen IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA
Isotype IgG2a kappa
Quantity 100μL
Regulatory Status RUO
Research Discipline Neuroscience
Type Primary
Monoclonal or Polyclonal Monoclonal
Target Species Human
Target Species Rabbit

Provide accurate, reproducible results with the Thermo Scientific™ IGF-1R (α-Subunit) Ab-3, Mouse Monoclonal Antibody.

IGF-1R (Insulin-like Growth Factor-1 Receptor) consists of α- and Β-subunits, which are disulfide-linked in a Β-α-α-Β configuration in the mature receptor. The α-subunit is completely extracellular, while the Β-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity.

Host Species: Mouse

Clone: 24-57

Isotype: IgG1/κ

Species Reactivity: Human and Rabbit. Weakly reacts with Pig. Does not react with rat.

Epitope: aa 440-514 (exon 7/8)

Immunogen: IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA

Molecular Weight: 125kDa

Positive Control: Placenta or Breast CA

Cellular Localization: Membrane Ab-3 is the antibody-of-choice for blocking binding of IGF-1 to its receptor. It weakly mimics IGF-1 action. Ab-3 reacts only weakly with hybrids of Insulin Receptor and IGF-1R while Ab-5 reacts very well. So, Ab-3, in conjunction with Ab-5, has proved useful in the isolation of hybrid receptors.

Recommended for:

  • Western Blotting (Not suitable)
  • Immunoprecipitation (Not optimum)
  • Affinity Purification of Hybrid Receptors
  • Acts as a Weak IGF-like Agonist in Bioassays (Thymidine incorporation into DNA)
  • Inhibits (>90%) IGF-1 Binding

Note:

USA: RUO; Int'l: RUO