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Thermo Scientific™ IGF-1R (α -Subunit) Ab-3, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ IGF-1R (α-Subunit) Ab-3, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™  MS643P1ABX

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Catalog No. MS643P1ABX

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Description & Specifications

Specifications

Antigen IGF-1R (alpha-Subunit) Ab-3
Classification Monoclonal
Clone 24-57
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Rabbit
Format Concentrated
Host Species Mouse
Immunogen IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA
Isotype IgG2a kappa
Quantity 100µL
Regulatory Status RUO
Research Discipline Neuroscience
Type Primary

Provide accurate, reproducible results with the Thermo Scientific™ IGF-1R (α-Subunit) Ab-3, Mouse Monoclonal Antibody.

IGF-1R (Insulin-like Growth Factor-1 Receptor) consists of α- and Β-subunits, which are disulfide-linked in a Β-α-α-Β configuration in the mature receptor. The α-subunit is completely extracellular, while the Β-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity.

Host Species: Mouse

Clone: 24-57

Isotype: IgG1/κ

Species Reactivity: Human and Rabbit. Weakly reacts with Pig. Does not react with rat.

Epitope: aa 440-514 (exon 7/8)

Immunogen: IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA

Molecular Weight: 125kDa

Positive Control: Placenta or Breast CA

Cellular Localization: Membrane Ab-3 is the antibody-of-choice for blocking binding of IGF-1 to its receptor. It weakly mimics IGF-1 action. Ab-3 reacts only weakly with hybrids of Insulin Receptor and IGF-1R while Ab-5 reacts very well. So, Ab-3, in conjunction with Ab-5, has proved useful in the isolation of hybrid receptors.

Recommended for:

  • Western Blotting (Not suitable)
  • Immunoprecipitation (Not optimum)
  • Affinity Purification of Hybrid Receptors
  • Acts as a Weak IGF-like Agonist in Bioassays (Thymidine incorporation into DNA)
  • Inhibits (>90%) IGF-1 Binding

Note:

USA: RUO; Int'l: RUO