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I kappa B alpha (IKB-a) Rat anti-Human, Mouse, PE, Clone: MFRDTRK, eBioscience™

Rat Monoclonal Antibody

$201.55 - $477.05

Specifications

Antigen I kappa B alpha (IKB-a)
Clone MFRDTRK
Host Species Rat
Gene Alias Inhibitor of kappa B alpha
Species Reactivity Human, Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122411

 
affymetrix
12903641
25 tests Each for $201.55

501122412

 
affymetrix
12903642
100 tests Each for $477.05
Description & Specifications

Specifications

Antigen I kappa B alpha (IKB-a)
Clone MFRDTRK
Host Species Rat
Gene Alias Inhibitor of kappa B alpha
Species Reactivity Human, Mouse
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.125μg)/test

This MFRDTRK monoclonal antibody recognizes human and mouse nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha (I kappa B alpha). I kappa B alpha is one member of a family of cellular proteins that functions to inhibit classical/canonical NF-kappa B signaling by masking the nuclear localization signals (NLS) of NF-kappa B proteins and keeping them sequestered in an inactive state in the cytoplasm. Classical/canonical NF-kappa B signaling is initiated in response to myriad stimuli including engagement of T cell and B cell receptors, growth factors, and inflammatory stimuli (reactive oxygen species, TNF alpha, IL-1) and results in the activation of the I kappa B kinase (IKK) complex that includes IKK alpha, IKK beta, and NEMO. IKK phosphorylates I kappa B alpha resulting in its ubiquitination, degradation, and subsequent translocation of NF-kappa B transcription factor proteins into the nucleus.