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eBioscience™ Human Wnt-1, Recombinant Protein, Carrier-Free

Human Recombinant Protein

$158.05 - $1,651.55

Specifications

Name Wnt-1
Recombinant Yes
Conjugate Unlabeled
Purity >98%
Purification Method SDS-PAGE and HPLC
View More Specs
Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123517

 
ebioscience™
34869561
2μg Each for $158.05

501123518

 
ebioscience™
34869563
10μg Each for $346.55

501123519

 
ebioscience™
34869582
100μg Each for $1,651.55
Description & Specifications

Specifications

Name Wnt-1
Recombinant Yes
Conjugate Unlabeled
Purity >98%
Purification Method SDS-PAGE and HPLC
Source E. coli
For Use With (Application) Functional Assays
Molecular Weight 42kDa (mature form)
Storage Requirements Store lyophilized protein at less than or equal to -20°C. Reconstituted protein solution can be stored with carrier-protein (e.g., 0.1% BSA) at less than or equal to -20°C.

Wnt proteins constitute a family of secreted glyocoproteins that activate signal transduction pathways to mediate tissue homeostasis, cell fate, cell proliferation, and self-renewal. The canonical signaling pathway is initiated upon Wnt binding to a Frizzled family receptor and an LRP5/LRP6 coreceptor, which leads to activation of the beta-catenin cascade. Non-canonical Wnt signals are activated by binding to a Frizzled family receptor and ROR2 coreceptor. Extensive research has shown that deregulation of these pathways or its components can lead to cancer.

Human Wnt-1 is encoded as a 370 amino acid precursor that, upon secretion, is cleaved into a 343 amino acid (42 kDa) mature form. At the amino acid level, mature human Wnt-1 is approximately 99% identical to mature mouse Wnt-1. Depending on the tissue, Wnt-1 can activate the canonical and non-canonical signaling pathways. Studies have demonstrated its involvement in a variety of functions, including embryonic development and carcinogenesis. Wnt-1 signaling can also induce the phosphorylation and subsequent degradation of c-Myb.