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eBioscience™ Human TGF beta 1, Recombinant Protein, Carrier-Free

Human Recombinant Protein

$2,739.05 - $6,857.05

Specifications

Name TGF beta 1
Recombinant Yes
Conjugate Unlabeled
Purity >98%
Purification Method SDS-PAGE
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Products
Catalog Number Mfr. No. Quantity Price Quantity    

5018578

 
ebioscience™
34834882
100μg Each for $2,739.05

5018579

 
ebioscience™
34-8348-85
500μg Each for $6,857.05
Description & Specifications

Specifications

Name TGF beta 1
Recombinant Yes
Conjugate Unlabeled
Purity >98%
Purification Method SDS-PAGE
Source CHO Cells
For Use With (Application) Cytokine Bioassays
Molecular Weight Mature TGFb1 polypeptide has a predicted molecular mass of 12,794. On reducing SDS-PAGE the protein migrates as a 13kDa polypeptide and on non-reducing SDS page the cystine-linked homodimer migrates as a 25kDa protein.
Storage Requirements Store at less than or equal to -70°C.

Human TGF beta 1 (Transforming Growth Factor beta 1) is a member of a superfamily of homologous, disulfide-linked, homodimeric proteins that regulate the proliferation and differentiation of normal and transformed cells. Human TGF beta 1 is a 25 kDa protein with each subunit containing 112 aa residues. TGF beta 1 is secreted from the many cell types in a complex with LAP (Latency Associated Peptide) and also with LTBP (latent TGF beta binding protein). Disassociation is thought to happen in the extracellular matrix via proteases and/or integrins. Regulatory T cells are a recently identified source of TGF beta 1 thought to be a key player in their suppressive functions. TGF beta 1 binds through TGF beta receptors (of which there is a large family). The protein is highly conserved across all mammalian species.