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Human PAR2 Mouse anti-Human, Clone: SAM11, eBioscience™

Mouse Monoclonal Antibody

$133.32 - $322.08

Specifications

Antigen Human PAR2
Clone SAM11
Host Species Murine
Applications ELISA,Functional Assay,Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin),Microscopy
Regulatory Status RUO
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122799 Life Technologies
LS14969980
25μg Each for $133.32
501122800 Life Technologies
LS14969982
100μg Each for $322.08
Specifications

Description

The monoclonal antibody SAM11 recognizes human PAR2 (Protease activated receptor 2). PAR2 is a member of the PAR family which is a sub-family of the G protein coupled receptors (GPCR). Unlike most of the GPCR family members, PARs are not activated through ligand binding, but through proteolytic cleavage of the amino terminus. PAR2 activation is induced by trypsin, mast cell tryptase, neutrophil proteinase 3, tissue factor-factor VIIa-factor Xa, human kallikrein-related peptidases and membrane-tethered serine proteinase-1/matriptase-1. Unlike other PARs, PAR2 is not activated by thrombin. PAR2 is widely expressed in many tissues, including skin, liver, kidney, small intestine, and colon. PAR2 plays a key role in numerous inflammatory diseases and cancers. The SAM11 antibody has been reported to inhibit the ability of serine proteinases to activate PAR2.
Description & Specifications

Specifications

Human PAR2
Murine
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
SAM11
ELISA,Functional Assay,Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin),Microscopy
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL