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Human PAR2 Mouse anti-Human, Clone: SAM11, eBioscience™

Mouse Monoclonal Antibody

$143.55 - $346.55

Specifications

Antigen Human PAR2
Clone SAM11
Host Species Mouse
Species Reactivity Human
Applications Enzyme Linked Immunosorbent Assay
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122799

 
affymetrix
14969980
25μg Each for $143.55

501122800

 
affymetrix
14969982
100μg Each for $346.55
Description & Specifications

Specifications

Antigen Human PAR2
Clone SAM11
Host Species Mouse
Species Reactivity Human
Applications Enzyme Linked Immunosorbent Assay
Applications Functional Assay
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Microscopy
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody SAM11 recognizes human PAR2 (Protease activated receptor 2). PAR2 is a member of the PAR family which is a sub-family of the G protein coupled receptors (GPCR). Unlike most of the GPCR family members, PARs are not activated through ligand binding, but through proteolytic cleavage of the amino terminus. PAR2 activation is induced by trypsin, mast cell tryptase, neutrophil proteinase 3, tissue factor-factor VIIa-factor Xa, human kallikrein-related peptidases and membrane-tethered serine proteinase-1/matriptase-1. Unlike other PARs, PAR2 is not activated by thrombin. PAR2 is widely expressed in many tissues, including skin, liver, kidney, small intestine, and colon. PAR2 plays a key role in numerous inflammatory diseases and cancers. The SAM11 antibody has been reported to inhibit the ability of serine proteinases to activate PAR2.