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eBioscience™ Human IL-21, Recombinant Protein

Human Recombinant Protein

$209.88 - $526.68

Specifications

Structural Form A DNA sequence encoding the mature form of human IL-21amino acids Gln25-Ser155 accession # NM_021803 was expressed in E.coli
Purity >98%
Purification Method SDS-PAGE
Molecular Weight The protein has a predicted molecular mass of 17,150. The DTT reduced protein migrates as a 18kDa polypeptide on SDS-PAGE. The non-reduced protein migrates as a 17kDa polypeptide.
Concentration 0.1mg/mL
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Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501128820 Life Technologies
LS14821980
25μg Each for $526.68
509020 Life Technologies
LS14821962
5μg Each for $209.88
Specifications

Description

Human Interleukin-21 (IL-21) is a 131-amino acid protein with 57% identity to the mouse gene. It contains a 24-amino acid signal peptide and a 4-helix-bundle cytokine domain homologous to IL-2, IL-4 and IL-15. IL-21 stimulates B cell proliferation in an anti-CD40 dependent manner but inhibits B cell proliferation stimulated by IL-4 plus anti-IgM. IL-21 is induced by IL-6 in activated T cells, a process that is dependent on STAT3 but not on ROR-gamma. IL-21 induces Th17 differentiation and suppresses FOXP3 expression, which requires STAT3 and ROR-gamma.
Description & Specifications

Specifications

A DNA sequence encoding the mature form of human IL-21amino acids Gln25-Ser155 accession # NM_021803 was expressed in E.coli
SDS-PAGE
0.1mg/mL
NM_021803
Sterile liquid; 20mM sodium phosphate, pH 7.2, 0.6M NaCl, 1.0% BSA. 0.22μm filtered.
Cytokine Bioassays, ELISA Recombinant Standard
Unlabeled
Human
IL-21
>98%
The protein has a predicted molecular mass of 17,150. The DTT reduced protein migrates as a 18kDa polypeptide on SDS-PAGE. The non-reduced protein migrates as a 17kDa polypeptide.
E. coli
Less than 0.01ng/ug cytokine as determined by the LAL assay.
The ED50 of this protein, as measured by B9 cell proliferation assay, is less than or equal to 25ng/mL. This corresponds to a specific activity of greater than or equal to 4 x 104 Units/mg.
ELISA, FA
RUO
Interleukin-21, IL21
Yes