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eBioscience™ Human IL-17E (IL-25), Recombinant Protein, Carrier-Free

Human Recombinant Protein

$158.05 - $984.55

Specifications

Name IL-17E (IL-25)
Recombinant Yes
Conjugate Unlabeled
Purity >98%
Purification Method SDS-PAGE and HPLC
View More Specs
Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123526

 
ebioscience™
34873662
5μg Each for $158.05

501123527

 
ebioscience™
34873680
25μg Each for $346.55

501129167

 
ebioscience™
34-8736-82
100μg Each for $984.55
Description & Specifications

Specifications

Name IL-17E (IL-25)
Recombinant Yes
Conjugate Unlabeled
Purity >98%
Purification Method SDS-PAGE and HPLC
Source E. coli
For Use With (Application) Functional Assays
Molecular Weight 33.8kDa disulfide-linked homodimer of two 145 aa polypeptide chains
Storage Requirements Store lyophilized protein at less than or equal to -20°C. Reconstituted protein solution can be stored with carrier-protein (e.g., 0.1% BSA) at less than or equal to -20°C.

IL-17E, or IL-25, was first identified as an IL-17 family member on the basis of sequence homology. It was originally believed to be a Th2 cytokine based on the detection of mRNA transcripts in polarized Th2 cells, but expression was later observed in epithelial cells, eosinophils, and mast cells. Studies have confirmed the role of IL-17E as a potent inducer of type 2 immune responses. IL-17E signaling induces the differentiation of CD4+ T cells towards the Th2 lineage and upregulates expression of Th2 cytokines such as IL-4, IL-5, and IL-13. Administration of IL-17E also promotes symptoms of allergic asthma, such as eosinophil infiltration, airway hyperreactivity, and high circulating levels of IgE. IL-17E binds to IL-17BR, a receptor shared with IL-17B, and activates NF-kappa B pathways.