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Human IL-17 Quantikine ELISA Kit, R&D Systems


Manufacturer: r & d systems  RDSD1700

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Catalog No. D1700

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Description & Specifications

Specifications

Gene ID (Entrez) 3605
Product Type Solid Phase Sandwich ELISA
Packaging Quantity 1 Plate
Quantity 1 Kit
Sensitivity 15pg/mL
Sample Type Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma
Sample Volume Cell Culture Supernates (100μL), Serum (100μL), EDTA Plasma (100μL), Heparin Plasma (100μL), Citrate Plasma (100μL)
Species Human
Specificity Natural and recombinant human IL-17
Sufficient For Sufficient materials to run ELISAs on at least one 96-well plate

The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

Assay Type: Solid Phase Sandwich ELISA
Sample Type/Volume Required: Cell Culture Supernates (100μL), Serum (100μL), EDTA Plasma (100μL), Heparin Plasma (100μL), Citrate Plasma (100μL)
Sensitivity: 15pg/mL
Specificity: Natural and recombinant human IL-17
Cross Reactivity: <50% cross-species reactivity observed with species tested. <0.5% cross-reactivity observed with available related molecules.