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eBioscience™ Human Fc Receptor Binding Inhibitor, Purified

Can be used to inhibit the non-specific Fc-gamma receptor (FcγR)-mediated binding of mouse monoclonal antibodies used for flow cytometric analysis of human tissue.

Manufacturer:  Life Technologies LS14916173

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Catalog No. 501129053


Alert:

Contains Azide


Description

Description

A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. Four different classes of Fcy receptors have been identified: FcyRI (CD64), FcyRII (CD32), and FcyRIII (CD16), and they are expressed at varying levels in multiple cell lineages including high expression in myeloid, granulocyte and B cells. The biological function of the FcyR, including initiation of endocytosis, phagocytosis and antigen presentation, is elicited upon binding of host-immunoglobulin. The extent to which mouse monoclonal antibodies will bind to human FcyR varies depending on the isotype of the monoclonal antibody. Furthermore, different monoclonal antibodies of the same isotype will display different binding to human FcyRs.
Specifications

Specifications

Fc Receptor Binding Inhibitor
Flow Cytometric Analysis
1 mg/mL
Unconjugated
100 tests,100 Tests
Fc blocking; FcR Inhibitor; Fc Receptor Inhibitor; FcR BI
Affinity chromatography
Antibody
Polyclonal
Human
Flow Cytometry
Polyclonal
Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Purified
Liquid
2° to 8°C
RUO
Primary
Human
Documents

For Research Use Only