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eBioscience™ Human Erythropoietin (EPO), Recombinant Protein

Human Recombinant Protein

$143.55 - $680.05

Specifications

Name Erythropoietin (EPO)
Recombinant Yes
Conjugate Unlabeled
Purity >96%
Purification Method SDS-PAGE
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Products
Catalog Number Mfr. No. Quantity Price Quantity    

5018568

 
ebioscience™
14899262
5μg Each for $143.55

5018569

 
ebioscience™
14899280
25μg Each for $680.05
Description & Specifications

Specifications

Name Erythropoietin (EPO)
Recombinant Yes
Conjugate Unlabeled
Purity >96%
Purification Method SDS-PAGE
Source CHO Cells
For Use With (Application) Cytokine Bioassays
Molecular Weight The predicted molecular mass of this protein is 20.6kDa. It migrates at 34kDa by SDS-PAGE due to glycosylation.
Storage Requirements For greatest stability, keep concentration of primary stock at or above 10μg/mL. For long term storage, aliquot into polypropylene vials (volumes of 20μL or greater) and store at less than or equal to -70°C. Avoid repeated freeze/thaw cycles.

Erythropoietin (EPO) protein is a growth factor essential for the survival, proliferation, and differentiation of erythroid precursors. EPO is not responsible for early commitment to the lineage, and instead induces the final maturation of partially differentiated erythroid cells and the production of red cell-specific proteins, such as hemoglobin. The EPO receptor (EPOR) is present in higher levels on precursor cells, and expression diminishes with cell maturation.

Hepatocytes are the main source of EPO in the fetus, followed by interstitial cells of the kidney after birth and through adulthood. EPO expression is upregulated during hypoxia, and low levels of transcription have also been detected in lung and brain tissue under these conditions. Recent data suggest that EPO may also play a role in the protection of neuronal tissue from damage and initiation of repair.