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eBioscience™ Human CD257 (BAFF, BLyS), Recombinant Protein

Human Recombinant Protein

$158.05 - $346.55

Specifications

Name CD257 (BAFF, BLyS)
Recombinant Yes
Conjugate Unlabeled
Purity >90%
Purification Method reducing SDS-PAGE
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Products
Catalog Number Mfr. No. Quantity Price Quantity    

5018543

 
ebioscience™
14-8943-62
5μg Each for $158.05

5018544

 
ebioscience™
14894380
25μg Each for $346.55
Description & Specifications

Specifications

Name CD257 (BAFF, BLyS)
Recombinant Yes
Conjugate Unlabeled
Purity >90%
Purification Method reducing SDS-PAGE
Source E. coli
For Use With (Application) Cytokine Bioassays
Molecular Weight 18.5kDa
Storage Requirements Store at less than or equal to -70°C.

Recombinant human BAFF (B-cell activating factor), also referred to as BlyS, is a type II transmembrane protein of the TNF superfamily. BAFF is found on T cells, macrophages and dendritic cells. BAFF contains a cytoplasmic domain, transmembrane domain and extracellular domain which can be cleaved between amino acid 133 and 134 to produce a soluble form detectable in serum. Receptors for BAFF include TACI, BAMBI and BAFFR. BAFF/BLyS is a B lymphocyte stimulatory molecule; it induces B cell proliferation and immunoglobulin secretion. In addition BAFF can provide a co-stimulation signal to T lymphocytes. Elevated levels of BAFF has been implicated in the pathogenesis of some autoimmune diseases (particularly) B cell diseases such as systemic lupus erythaematosus. Human and mouse BAFF share 86% amino acid sequence identity.