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eBioscience™ Human CD25, Recombinant Protein, Carrier-Free

Human Recombinant Protein

$346.55 - $955.55

Specifications

Name CD25
Recombinant Yes
Conjugate Unlabeled
Purity >98%
Purification Method SDS-PAGE and HPLC
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Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123522

 
ebioscience™
34870280
25μg Each for $346.55

501123523

 
ebioscience™
34870282
100μg Each for $955.55
Description & Specifications

Specifications

Name CD25
Recombinant Yes
Conjugate Unlabeled
Purity >98%
Purification Method SDS-PAGE and HPLC
Source Insect Cells
For Use With (Application) Functional Assays
Molecular Weight 24.8kDa
Storage Requirements Store lyophilized protein at less than or equal to -20°C. Reconstituted protein solution can be stored with carrier-protein (e.g., 0.1% BSA) at less than or equal to -20°C.

The human soluble IL-2 receptor alpha chain (sIL-2Ra) is generated by proteolytic cleavage of the cell-surface bound receptor on activated T cells. The IL-2Ra (also known as CD25) is expressed by early progenitors of the T and B lineage, as well as by activated mature T and B lymphocytes. By itself, CD25 binds IL-2 with low affinity. However, association with CD122 (IL-2 receptor beta chain) and CD132 (common gamma chain) results in formation of the high affinity IL-2R. CD25 plays a role in lymphocyte differentiation and activation/proliferation. sIL-2Ra has been detected in the serum of patients with autoimmune disease and leukemia. Reports have demonstrated that addition of sIL-2Ra can inhibit IL-2-mediated signaling and enhance Th17 responses.