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eBioscience™ Human Brain-Derived Neurotrophic Factor (BDNF), Recombinant Protein

Human Recombinant Protein

$187.05 - $564.05

Specifications

Name Brain-Derived Neurotrophic Factor (BDNF)
Recombinant Yes
Conjugate Unlabeled
Purity ≥97%
Purification Method SDS-PAGE
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Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122734

 
ebioscience™
14836662
5μg Each for $187.05

501122735

 
ebioscience™
14836680
25μg Each for $564.05
Description & Specifications

Specifications

Name Brain-Derived Neurotrophic Factor (BDNF)
Recombinant Yes
Conjugate Unlabeled
Purity ≥97%
Purification Method SDS-PAGE
Source E. coli
For Use With (Application) Cytokine Bioassays
Molecular Weight 15.4kDa
Storage Requirements Store at less than or equal to -70°C.

Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, proBDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation.