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HLA-G Mouse anti-Human, Clone: 87G, eBioscience™

Mouse Monoclonal Antibody

$91.08 - $143.88

Specifications

Antigen HLA-G
Clone 87G
Host Species Murine
Applications Flow Cytometry,Immunohistochemistry (Frozen)
Regulatory Status RUO
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5013919 Life Technologies
LS14995780
25μg Each for $91.08
5013920 Life Technologies
LS14995782
100μg Each for $143.88
Specifications

Description

The monoclonal antibody 87G recognizes human HLA-G, a member of the Human Leukocyte Antigen family but as part of the nonclassical MHC type involved in inhibiting immune reponses. HLA-G has seven reported isoforms. The antibody 87G recognizes both HLA-G1 and the solube HLA-G5. Expression of HLA-G is found primarily in fetal trophoblast cells as they invade the maternal decidua thereby protecting the fetus from the maternal immune system. Like the highly mitotic trophoblast, abundant HLA-G protein expression has been identified in some tumors, including melanoma, breast carcinoma and renal carcinoma as well as CLL, AML and B-CLL. Some expression has also been found in pancreatic islets, erythroid and endothelial progenitors and the adult thymic medulla.HLA-G+ CD4 or CD8 cells have been identified in normal human peripheral blood and are thought to act as regulatory cells in that they are hypoproliferative with a unique cytokine profile differing from Tregs. The receptors for HLA-G are CD85j/ILT2, CD85d/ILT4, and CD158. Recent studies have shown a role for HLA-G in tolerance and maintenance of transplanted organs.
Description & Specifications

Specifications

HLA-G
Murine
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
87G
Flow Cytometry,Immunohistochemistry (Frozen)
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL