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Tocris™ HKI 357

Dual irreversible inhibitor of ErbB2 and EGFR

$320.01 - $1,348.18

Specifications

Product Type HKI 357
Inhibitors HKI 357
Molecular Weight 574.05
Purity >98
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 Disclaimers

For Research Use Only

Products
Catalog Number Mfr. No. Quantity Price Quantity    

358010R

 
tocris™
3580/10
10mg Each for $320.01

358050R

 
tocris™
3580/50
50mg Each for $1,348.18
Description & Specifications

Specifications

Product Type HKI 357
Inhibitors HKI 357
Molecular Weight 574.05
Purity >98

Potent, irreversible inhibitor of ErbB2 (HER2) and EGFR (IC50 values are 33 and 34nM respectively). Suppresses ligand-induced EGFR autophosphorylation and cell proliferation in NCI-H1975 cells containing L858R and T790M mutations. Circumvents mechanisms of resistance to Iressa (Cat. No. 3000) in non-small-cell lung cancer cells.

  • Chemical Name: (2E)-N-[[4-[[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
  • Formula: C31H29ClFN5O3
  • CAS Number: 848133-17-5
  • Solubility: Soluble to 100mM in DMSO and to 25mM in ethanol
  • Purity: >98