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Tocris™ HKI 357

Dual irreversible inhibitor of ErbB2 and EGFR

$320.76 - $1,323.85

Specifications

Product Type HKI 357
Inhibitors HKI 357
Molecular Weight 574.05
Purity >98
View More Specs

Disclaimers:

For Research Use Only



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
358010R Tocris™
RDS358010
10mg Each for $320.76
358050R Tocris™
RDS358050
50mg Each for $1,323.85
Specifications

Description

Potent, irreversible inhibitor of ErbB2 (HER2) and EGFR (IC50 values are 33 and 34nM respectively). Suppresses ligand-induced EGFR autophosphorylation and cell proliferation in NCI-H1975 cells containing L858R and T790M mutations. Circumvents mechanisms of resistance to Iressa (Cat. No. 3000) in non-small-cell lung cancer cells.
  • Chemical Name: (2E)-N-[[4-[[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
  • Formula: C31H29ClFN5O3
  • CAS Number: 848133-17-5
  • Solubility: Soluble to 100mM in DMSO and to 25mM in ethanol
  • Purity: >98
Description & Specifications

Specifications

HKI 357
HKI 357
574.05
>98