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High Endothelial Venule Marker Rat anti-Human, Mouse, Alexa Fluor 488, Clone: MECA-79, eBioscience™

Rat Monoclonal Antibody

$201.55 - $506.05

Specifications

Antigen High Endothelial Venule Marker
Clone MECA-79
Host Species Rat
Gene Alias HEV, PNAd, MECA-79
Species Reactivity Human, Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

50246085

 
affymetrix
53603680
25μg Each for $201.55

50246086

 
affymetrix
53603682
100μg Each for $506.05
Description & Specifications

Specifications

Antigen High Endothelial Venule Marker
Clone MECA-79
Host Species Rat
Gene Alias HEV, PNAd, MECA-79
Species Reactivity Human, Mouse
Applications Flow Cytometry
Applications Immunohistochemistry (Formalin/Paraffin)
Regulatory Status RUO
Conjugate Alexa Fluor 488
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

This MECA-79 monoclonal antibody recognizes a sulfated carbohydrate epitope present on human and mouse high endothelial venules (HEVs) called peripheral lymph node addressin (PNAd). This glycoprotein is expressed on the luminal surface and in the cytoplasm of HEVs in lymphoid tissues, including peripheral and mesenteric lymph nodes and, to a lesser extent, Peyer’s patches. The MECA-79 antigen has also been detected on follicular B cells in the spleen and appendix in humans, as well as at sites of chronic inflammation. Post-capillary venules or large vessels in the spleen, thymus, or non-lymphoid tissues do not express the MECA-79 antigen and thus cannot be detected with this antibody. This addressin is involved in lymphocyte infiltration and adhesion into secondary lymphoid tissues.

The MECA-79 antibody has been reported to inhibit CD62L (L-selectin)-dependent lymphocyte emigration to HEVs and adhesion in lymph nodes and tonsils.