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HIF-1 Mouse, Clone: ESEE122, eBioscience™

Mouse Monoclonal Antibody

$146.52 - $361.68

Specifications

Antigen HIF-1
Clone ESEE122
Host Species Murine
Gene Alias ARNT interacting protein, hypoxia inducible factor-1
Species Reactivity Bovine, Human, Mouse, Rat
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122756 Life Technologies
LS14910080
25μg Each for $146.52
501122757 Life Technologies
LS14910082
100μg Each for $361.68
Specifications

Description

This ESEE122 monoclonal antibody reacts with hypoxia inducible factor-1 alpha. The hypoxia inducible factor (HIF-1) is a transcription factor composed of an inducible alpha form and the constitutively expressed beta form, also called the aryl hydrocarbon receptor nuclear translocator (ARNT). Both alpha and beta subunits of HIF-1 contain basic helix-loop-helix motifs and function to activate transcription of genes in response to reduced oxygen levels. Under normoxic conditions, HIF-1 alpha is rapidly degraded, while HIF-1 alpha expression is induced and degradation inhibited under hypoxic conditions. HIF-1 alpha can be found in the cytoplasm and/or in the nucleus under normoxic conditions, but translocates to the nucleus under hypoxic conditions. HIF-1 is upregulated in several cancer types and functions to control genes involved in angiogenesis, cell survival and T cell development. Recent studies have shown the importance of HIF-1 alpha in balancing Th17 and Treg development.

This ESEE122 antibody has also been reported to cross-react with bovine, rat, and mouse hypoxia inducible factor-1 alpha.
Description & Specifications

Specifications

HIF-1
Murine
Bovine, Human, Mouse, Rat
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
ESEE122
ARNT interacting protein, hypoxia inducible factor-1
Immunocytochemistry,Immunohistochemistry,Immunohistochemistry (Formalin/Paraffin)
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL