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HIF-1 Mouse, Clone: ESEE122, eBioscience™

Mouse Monoclonal Antibody

$158.05 - $390.05

Specifications

Antigen HIF-1
Clone ESEE122
Host Species Mouse
Gene Alias ARNT interacting protein, hypoxia inducible factor-1
Species Reactivity Bovine, Human, Mouse, Rat
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122756

 
affymetrix
14910080
25μg Each for $158.05

501122757

 
affymetrix
14910082
100μg Each for $390.05
Description & Specifications

Specifications

Antigen HIF-1
Clone ESEE122
Host Species Mouse
Gene Alias ARNT interacting protein, hypoxia inducible factor-1
Species Reactivity Bovine, Human, Mouse, Rat
Applications Immunocytochemistry
Applications Immunohistochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

This ESEE122 monoclonal antibody reacts with hypoxia inducible factor-1 alpha. The hypoxia inducible factor (HIF-1) is a transcription factor composed of an inducible alpha form and the constitutively expressed beta form, also called the aryl hydrocarbon receptor nuclear translocator (ARNT). Both alpha and beta subunits of HIF-1 contain basic helix-loop-helix motifs and function to activate transcription of genes in response to reduced oxygen levels. Under normoxic conditions, HIF-1 alpha is rapidly degraded, while HIF-1 alpha expression is induced and degradation inhibited under hypoxic conditions. HIF-1 alpha can be found in the cytoplasm and/or in the nucleus under normoxic conditions, but translocates to the nucleus under hypoxic conditions. HIF-1 is upregulated in several cancer types and functions to control genes involved in angiogenesis, cell survival and T cell development. Recent studies have shown the importance of HIF-1 alpha in balancing Th17 and Treg development.

This ESEE122 antibody has also been reported to cross-react with bovine, rat, and mouse hypoxia inducible factor-1 alpha.